ADENOSINE DEAMINASE LEVEL IN DRUG RESISTANT TUBERCULOSIS

Tuberculosis (TB) remains one of the health problems in Nigeria and worldwide. Adenosine Deaminase acts proliferation differentiation lymphocyte, especially T lymphocyte. It also maturation monocytes transforming them to macrophage. is a significant indicator active cellular immunity. has been proposed be useful surrogate marker for TB because it can detected body fluids such as pleural, pericardial peritoneal fluid. This study aimed determine relationship between drug Resistant (DR-TB) among patients attending Clinic Government Chest Hospital, Jericho, Oyo State, Nigeria. Methodology: A prospective case-control involving thirty (30) Multi-Drug Resistance apparently healthy participants Theparticipants socio-demographic data was obtained using questionnaire. Sputum samples were collected from each patient two groups leak proof screw capped specimen containers. About 5 mL venous blood sample antecubital fossa into vacutainer plain tubes. analysed Mycobacterium tuberculosis Gene Xpert. Blood analyzed ELISA method. The prevalence MDR-TB 0.18%, majority within age 15-30 years with mean 36.30±13.40 female having 63.3% male 36.7%. Among MDR-TB, mean±SD activity 37.67±15.25 IU/L Healthy controls, 12.26±5.11 IU/L. There significance increased ADA when compared controls at p-value<0.05 (p=0.001). level 18 cut off point sensitivity 90.0%, specificity 87.0% diagnostic accuracy 88.0%. In conclusion, there moderately high participants. levels MDR-TB. High observed might alternative test diagnose rule out resistance tuberculosis.